Bone, cartilage, and fat muscles are all
formed from a common pool of embryonic mesoderm cells. The type of tissue
(bone, fat or cartilage) that develops depends on specific stimulation that is
produced through cellular signals. Signals involved in bone formation
(osteogenesis), cartilage (chondrogenesis) and fat muscle (adipogenesis) are
not well known. Shown in the diagram
below, we plan to use murine C3H10T1/2 cells to analyze the effect of sICD on osteogenesis, chondrogenesis, and
adipogenesis. We will further look at the genes that are affected by these
assays to identify potential regulators of these cellular differentiation
processes.
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