As mentioned earlier, we have been working
on identifying gene targets for soluble FGFR3 cleaved sICD fragment using
ChIP-sequencing. We have made considerable progress in optimizing the protocol
for this experiment and have also initiated our first ChIP-sequencing
experiment. We are beginning to prepare for additional
ChIP-sequencing experiments based on the results from our preliminary
investigation.
Additionally, the Ach-mutant transgenic
mice line is being established. We have a few different transgenic lines in our
facility that are in the process of being genotyped to confirm their genetic
make-up. Once confirmed, we will start using them initially to perform certain immunohistochemistry
and protein studies.
